This online webinar demonstrates the implementation and analysis of pharmacokinetic, pharmacodynamic and physiologically-based pharmacokinetic models using the acslX modeling and simulation environment.

By developing and analyzing a few example models, we will introduce you to the acslX environment and show you how acslX can be used in applications ranging from prediction of drug dispersion and therapeutic thresholds, to determination of exposure limits for toxicological risk assessment.

Topics discussed during the webinar will include:

• Import and exploration of clinical/laboratory data in the acslX environment
• Specification of PK models using both the CSL language and the PK toolkit for graphical modeling
• Estimation of PK parameters using maximum likelihood parameter estimation in acslX
• Linking a PD model to an acslX kinetic model
• Prediction of the effects of various dosing regimens using the acslX analysis language ("M language")
• Using an acslX PBPK model to predict internal dose metrics from toxic exposure
• Animal to human extrapolation using an acslX PBPK model
• Determination of external exposure limits based on internal dose metrics
• Uncertainty analysis of acslX model predictions using Monte Carlo techniques